Still have questions
about your immune deficiency?
It's time
for answers
If you are being treated for recurrent infections or neutropenia but continue to struggle with managing your symptoms, it could be something else. It could be WHIM syndrome—a specific and diagnosable immunodeficiency that weakens the body's ability to fight infections.
Signs and Symptoms
Learn about the common signs and symptoms of WHIM syndrome: recurrent infections, low levels of white blood cells, low antibodies, and others.
No-Cost Genetic Testing
If you think you may have WHIM syndrome, a genetic test using a simple cheek swab can help you find answers.
X4 Nurse Educator Support*
A resource who specializes in WHIM syndrome can help you and your family find answers through one-on-one education and resources.
*X4 Nurse Educators are employees of X4 Pharmaceuticals and do not work under the direction of a healthcare professional; they do not offer medical or treatment-related advice. For treatment and medical questions, you should contact your healthcare provider.
What is
WHIM syndrome?
WHIM syndrome is a rare type of primary immunodeficiency (PI). PIs are genetic conditions that weaken the body’s immune system, making it difficult to fight infections.
WHIM syndrome is named for 4 signs and symptoms: Warts, Hypogammaglobulinemia,†
Infections, and Myelokathexis.‡
Some are more common than others:
% of People With Each Sign or Symptom
†Hypogammaglobulinemia is the medical term for low levels of antibodies in the bloodstream.
‡Myelokathexis is the medical term for when infection-fighting white blood cells called neutrophils become trapped in the bone marrow. It is discovered through a bone marrow biopsy.
Despite its name, only 23% of people with WHIM syndrome have all 4. There are other signs and symptoms to look for beyond the acronym.
What causes
WHIM syndrome?
The main cause of WHIM syndrome is a variation in the CXCR4 gene, which is part of your DNA.
This variation causes low levels of white blood cells in the body.
Without a healthy amount of these white blood cells circulating in the bloodstream, the body is immunocompromised and more vulnerable to infections.
*X4 Nurse Educators are employees of X4 Pharmaceuticals and do not work under the direction of a healthcare professional; they do not offer medical or treatment-related advice. For treatment and medical questions, you should contact your healthcare provider.